Article published Open Source in: Clin Orthop Surg. 2020 Dec;12(4):417-429.
Authors: Cho TJ, Ko JM, Kim H, Shin HI, Yoo WJ, Shin CH
Content:
What is This Article About?
This article reviews how to manage Osteogenesis Imperfecta (OI), also known as “brittle bone disease,” with a focus on medical treatments, physical therapy, and surgical options. It provides an overview of how different approaches work together to improve quality of life for people with OI.
Key Aspects of Management:
Medical Treatments:
- Bisphosphonates: These medications are commonly used to strengthen bones, increase bone density, and reduce fractures. They are especially effective in children with severe OI.
- New treatments, like sclerostin-blocking antibodies and RANKL inhibitors, are being studied and show promise in improving bone strength.
Physical Therapy and Rehabilitation:
- Therapy focuses on improving strength, mobility, and independence.
- Activities like standing programs, water exercises, and weight-bearing exercises are encouraged to build muscle and bone strength.
- Assistive devices, such as braces and walkers, help with movement and safety.
Surgical Treatments:
- Telescopic Rods: These are metal rods inserted into long bones to straighten and stabilize them. They grow with the bone, reducing the need for repeated surgeries.
- Surgery is also used to correct deformities or stabilize fractures.
Managing Complications:
- Special care is needed to monitor and treat spinal issues like scoliosis and cranial problems (e.g., basilar invagination, which can affect the brainstem).
- Regular imaging and check-ups help detect and manage these complications early.